Gaik A, Brzezińska-Błaszczyk E, Jarzebska M, Prochowski M, Karczewska M
Kliniki Chorób Płuc IMW WAM, Lodzi.
Pneumonol Alergol Pol. 1992;60(1-2):23-7.
We have studied the sensitivity of pulmonary mast cells and blood basophils in patients with sarcoidosis and bronchial asthma. The cells were induced in vitro with anti-IgE. The histamine releasing from mast cells and basophils was high in both examined groups of patients. The histamine releasing from mast cells in patients with sarcoidosis was 27.8-47.1% and in asthmatic patients 42.8-58.9%. The histamine releasing from basophils was 38.2-57.9% and 41.0-62.1%, respectively. The high sensitivity of mast cells of patients with sarcoidosis may suggest that these cells play an essential role in pathology of this disease.
我们研究了结节病和支气管哮喘患者肺肥大细胞和血液嗜碱性粒细胞的敏感性。这些细胞在体外由抗IgE诱导。在两组受试患者中，肥大细胞和嗜碱性粒细胞释放组胺的水平都很高。结节病患者肥大细胞释放组胺的比例为27.8 - 47.1%，哮喘患者为42.8 - 58.9%。嗜碱性粒细胞释放组胺的比例分别为38.2 - 57.9%和41.0 - 62.1%。结节病患者肥大细胞的高敏感性可能表明这些细胞在该疾病的病理过程中起重要作用。
