色甘酸钠和奈多罗米钠对人肺肥大细胞组胺分泌的影响。
Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.
作者信息
Leung K B, Flint K C, Brostoff J, Hudspith B N, Johnson N M, Lau H Y, Liu W L, Pearce F L
机构信息
Department of Chemistry, University College London.
出版信息
Thorax. 1988 Oct;43(10):756-61. doi: 10.1136/thx.43.10.756.
Abstract
Sodium cromoglycate and nedocromil sodium produced a dose dependent inhibition of histamine secretion from human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of lung parenchyma. Both compounds were significantly more active against the lavage cells than against the dispersed lung cells, and nedocromil sodium was an order of magnitude more effective than sodium cromoglycate against both cell types. Tachyphylaxis was observed with the parenchymal cells but not with the lavage cells. Nedocromil sodium and sodium cromoglycate also inhibited histamine release from the lavage cells of patients with sarcoidosis and extrinsic asthma.
摘要
色甘酸钠和奈多罗米钠对通过支气管肺泡灌洗和肺实质酶解获得的人肺肥大细胞组胺分泌产生剂量依赖性抑制作用。这两种化合物对灌洗细胞的活性均明显高于对分散的肺细胞的活性，并且奈多罗米钠对两种细胞类型的效力比色甘酸钠高一个数量级。在实质细胞中观察到快速耐受性，但在灌洗细胞中未观察到。奈多罗米钠和色甘酸钠也抑制结节病和外源性哮喘患者灌洗细胞中的组胺释放。
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