Flint K C, Leung K B, Hudspith B N, Brostoff J, Pearce F L, Geraint-James D, Johnson N M
Thorax. 1986 Feb;41(2):94-9. doi: 10.1136/thx.41.2.94.
Bronchoalveolar lavage was carried out in 36 subjects with sarcoidosis and 20 control subjects undergoing bronchoscopy for routine diagnostic purposes. The proportion of mast cells in the lavage fluid of subjects with sarcoidosis (mean (SE) 0.84% 0.09%; p less than 0.01) when compared with that of controls (mean 0.32% (0.05%); p less than 0.01). This increase was greatest in subjects with positive gallium scans but was not correlated with the percentage recovery of lymphocytes or radiographic stage. Anti-IgE induced histamine release from the bronchoalveolar cells of 15 subjects with sarcoidosis was significantly increased at all effective doses of anti-IgE. This accentuation of histamine release was significantly greater in patients with positive gallium scans and correlated directly with the percentage recovery of lymphocytes (r = 0.7, p less than 0.005). The dose-response curve of anti-IgE induced histamine release from bronchoalveolar cells of subjects with more than 20% of lymphocytes in the lavage cell population was significantly greater than the dose-response curves of subjects with fewer than 20% of lymphocytes and of controls.
对36例结节病患者和20例因常规诊断目的接受支气管镜检查的对照者进行了支气管肺泡灌洗。与对照组相比，结节病患者灌洗液中肥大细胞的比例（均值（标准误）0.84% 0.09%；p<0.01），对照组为均值0.32%（0.05%）；p<0.01。这种增加在镓扫描阳性的患者中最为明显，但与淋巴细胞回收率或放射学分期无关。在所有有效剂量的抗IgE作用下，15例结节病患者支气管肺泡细胞的抗IgE诱导组胺释放显著增加。镓扫描阳性的患者中组胺释放的这种增强更为显著，且与淋巴细胞回收率直接相关（r = 0.7，p<0.005）。灌洗细胞群中淋巴细胞超过20%的受试者支气管肺泡细胞的抗IgE诱导组胺释放的剂量反应曲线显著高于淋巴细胞少于20%的受试者和对照组的剂量反应曲线。
