淋巴细胞增生性疾病患者淋巴细胞的混合淋巴细胞培养刺激和反应能力。
Mixed lymphocyte culture stimulatory and responding capacity of lymphocytes from patients with lymphoproliferative diseases.
作者信息
Rühl H, Vogt W, Bochert G, Schmidt S, Moelle R, Schaoua H
出版信息
Clin Exp Immunol. 1975 Jan;19(1):55-65.
Abstract
Lymphocyte reactivity in vitro was studied in patients with Hodgkin's disease, chronic lymphocytic leukaemia and lymphosarcoma. The responding capacity to phytohaemagglutinin (PHA) was markedly depressed and delayed in all three groups of patients compared with the PHA response observed in lymphocyte cultures from normal individuals. In one-way mixed lymphocyte culture experiments a significant decrease in responding capacity of the patients' lymphocytes to lymphocytes from normal donors could be demonstrated. In contrast, the stimulatory capacity of the patients' lymphocytes was found to be intact, or only slightly reduced.
摘要
对霍奇金病、慢性淋巴细胞白血病和淋巴肉瘤患者的淋巴细胞体外反应性进行了研究。与正常个体淋巴细胞培养物中观察到的植物血凝素（PHA）反应相比，这三组患者对PHA的反应能力均明显降低且延迟。在单向混合淋巴细胞培养实验中，可以证明患者淋巴细胞对正常供体淋巴细胞的反应能力显著下降。相比之下，发现患者淋巴细胞的刺激能力是完整的，或仅略有降低。
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本文引用的文献
1
Differentiation of human leukemic leukocytes in tissue culture.
Exp Cell Res. 1960 Mar;19:267-77. doi: 10.1016/0014-4827(60)90007-0.
2
IMMUNOLOGIC AND CYTOGENETIC STUDIES OF CHRONIC LYMPHOCYTIC LEUKEMIC CELLS.
Blood. 1965 Aug;26:121-32.
3
HODGKIN'S DISEASE--PROGNOSIS, TREATMENT AND ETIOLOGIC AND IMMUNOLOGIC CONSIDERATIONS.
N Engl J Med. 1964 Mar 5;270:508-14 CONTD. doi: 10.1056/NEJM196403052701006.
4
Studies on delayed hypersensitivity in Hodgkin's disease.
J Clin Invest. 1962 Nov;41(11):1964-70. doi: 10.1172/JCI104654.
5
Effects of phytohemagglutinin on rat and normal and leukemic human blood cells.
Proc Soc Exp Biol Med. 1963 May;113:191-4. doi: 10.3181/00379727-113-28317.
6
7
Homologous and heterologous skin transplantation in patients with lymphomatous disease.
J Natl Cancer Inst. 1961 Mar;26:569-83.
8
An investigation of Hodgkin's disease with respect to the problem of homotransplantation.
Ann N Y Acad Sci. 1960 May 31;87:187-202. doi: 10.1111/j.1749-6632.1960.tb23192.x.
9
Hodgkin's disease. Immunologic, clinical, and histologic features of 50 untreated patients.
Ann Intern Med. 1967 Aug;67(2):291-302. doi: 10.7326/0003-4819-67-2-291.
10
Human peripheral blood in tissue culture and the action of phytohemagglutinin.
Experientia. 1964 Mar 15;20(3):164-8. doi: 10.1007/BF02150714.
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