在混合淋巴细胞培养中评估未经治疗的霍奇金病患者淋巴细胞的免疫能力。
Immunological capacity of lymphocytes from untreated patients with Hodgkin's disease evaluated in mixed lymphocyte culture.
作者信息
Björkholm M, Holm G, Mellstedt H, Pettersson D
出版信息
Clin Exp Immunol. 1975 Dec;22(3):373-7.
Abstract
Blood lymphocytes from thirty-nine untreated patients with Hodgkin's disease were tested for stimulatory and responding capacity in mixed lymphocyte culture. The response to allogeneic lymphocytes was impaired in ten patients but the mean response of the patient group did not differ from healthy controls. Lymphocytes from female patients responded better than male patients (P less than 0-02). The stimulatory efficacy was severely impaired in patients' lymphocytes (P less than 0-001). Age, clinical stage and histopathology had no significant influence on the responding or stimulatory capacity.
摘要
对39例未经治疗的霍奇金病患者的血液淋巴细胞进行混合淋巴细胞培养，检测其刺激和反应能力。10例患者对同种异体淋巴细胞的反应受损，但患者组的平均反应与健康对照无差异。女性患者的淋巴细胞反应优于男性患者（P小于0.02）。患者淋巴细胞的刺激效力严重受损（P小于0.001）。年龄、临床分期和组织病理学对反应或刺激能力无显著影响。
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Impaired in vitro lymphocyte transformation in Hodgkin's disease.霍奇金病患者体外淋巴细胞转化受损。
N Engl J Med. 1965 Nov 4;273(19):1006-12. doi: 10.1056/NEJM196511042731903.
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Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro.人粒细胞和淋巴细胞在体外对人成纤维细胞的不同作用。
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