Gorio A, Di Giulio A M, Tenconi B, Donadoni L, Germani E, Bertelli A, Mantegazza P, Maccari F, Ramacci M T
Department of Medical Pharmacology, Faculty of Medicine, University of Milan, Italy.
Int J Clin Pharmacol Res. 1992;12(5-6):225-30.
Autonomic neuropathy and gastrointestinal problems are among the most common complications of diabetes. In this report it is shown that a possible correlation between the two disorders might exist, since diabetes causes a profound alteration of the peptidergic innervation of the gut. It is reported that 14 weeks after diabetes induction with alloxan the levels of substance P and methionine-enkephalin are markedly reduced throughout the intestine, while vasoactive intestinal polypeptide content is dramatically increased. Therefore the enteric innervation of diabetic animals is completely disorganized, with some systems undergoing atrophy and others undergoing hypertrophy. Treatment of diabetic animals with acetyl-L-carnitine prevents the onset of the marked peptide changes described above. The results suggest a potential for acetyl-L-carnitine in the treatment of autonomic neuropathies.
自主神经病变和胃肠道问题是糖尿病最常见的并发症。本报告表明，这两种病症之间可能存在关联，因为糖尿病会导致肠道肽能神经支配发生深刻改变。据报道，用四氧嘧啶诱导糖尿病14周后，整个肠道内P物质和甲硫氨酸脑啡肽的水平显著降低，而血管活性肠肽含量则急剧增加。因此，糖尿病动物的肠神经支配完全紊乱，一些系统发生萎缩，另一些则发生肥大。用乙酰-L-肉碱治疗糖尿病动物可预防上述明显的肽变化的发生。结果表明乙酰-L-肉碱在治疗自主神经病变方面具有潜力。
