Zhao Z Z, Huang M T, Li Q
Hebei Cancer Institute, Shijiazhuang.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Oct;12(10):620-1, 582.
According to the principles of SOS response, the authors tested the mutational specificity of tea and its inhibitory effects to the mutational specificity of 6 antineoplastic drugs by using the method of mutational and anti-mutational synchronous test. The results revealed that the tea had no mutational toxicity but anti-mutation effect. It also had the inhibitory effect on mutational toxicity of 6 antineoplastic drugs, including Mitomycin C, Bleomycin, Fluorouracil, Cisdiaminodichoroplatinum, Arabinosylcytosin and Mustargen. These results have provided referential basis for further study on anti-cancer effect and clinical use of tea.
根据SOS反应原理，作者采用突变与抗突变同步试验方法，检测了茶叶的突变特异性及其对6种抗肿瘤药物突变特异性的抑制作用。结果表明，茶叶无致突变毒性，却有抗突变作用。它对丝裂霉素C、博来霉素、氟尿嘧啶、顺铂、阿糖胞苷、氮芥等6种抗肿瘤药物的致突变毒性也有抑制作用。这些结果为进一步研究茶叶的抗癌作用及临床应用提供了参考依据。
