Zhao Z Z, Huang M T
Hebei Cancer Institute, Shi Jiazhuang.
Zhonghua Yu Fang Yi Xue Za Zhi. 1992 Sep;26(5):291-3.
The inhibitory effects on the mutational specificity of antineoplastic drugs of 14 kinds of vitamin were tested with the method of mutational and anti-mutational synchoronous test, add S9 and no S9. Vit C, Vit B6, and nicotinic acid had distinct inhibitory effects on the mutational specificity of 6 antineoplastic drugs, namely, mitomycin C, bleomycin, fluorouracil, cis-Diaminodichloroplatinum, arabinosylcytosine and mustargen Vit K3 showed inhibitory effect to mitomycin C, fluorouracil, cis-diaminodichloroplatinum, and arabinosylcytosine but Vit AD, Vit B1, Vit B2, Vit Bco, Vit D3, Vit E, Rutin, Vit K1, Vit K4 and folic acid did not. The fact that Vit C, Vit B6, nicotinic acid and Vit K3 showed anti-mutational effects is of some significance with reference to clinical therapeutics and prevention of tumours.
采用突变与抗突变同步试验法，添加S9和不添加S9的情况下，检测了14种维生素对抗肿瘤药物突变特异性的抑制作用。维生素C、维生素B6和烟酸对6种抗肿瘤药物（丝裂霉素C、博来霉素、氟尿嘧啶、顺式二氨基二氯铂、阿糖胞苷和氮芥）的突变特异性有明显抑制作用。维生素K3对丝裂霉素C、氟尿嘧啶、顺式二氨基二氯铂和阿糖胞苷有抑制作用，但维生素AD、维生素B1、维生素B2、复合维生素B、维生素D3、维生素E、芦丁、维生素K1、维生素K4和叶酸则没有。维生素C、维生素B6、烟酸和维生素K3具有抗突变作用这一事实，对于肿瘤的临床治疗和预防具有一定意义。
