Sedjo Rebecca L, Papenfuss Mary R, Craft Neal E, Giuliano Anna R
Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724-5024, USA.
Cancer Causes Control. 2003 May;14(4):319-26. doi: 10.1023/a:1023981505268.
Data have suggested that higher levels of nutrients are protective against HPV persistence and cervical neoplasia. This study assessed the role of circulating nutrients on clearance of oncogenic HPV infections.
Women were followed prospectively with visits at baseline and approximately 4- and 10-months post-baseline. At each visit, 15 oncogenic HPV types were determined. Plasma levels were assessed at the 4-month visit for retinol, carotenoids (i.e., alpha-, trans-beta-, cis-beta-carotene, alpha-, beta-cryptoxanthin, lutein, zeaxanthin, trans- and cis-lycopene), tocopherols (i.e., alpha-, delta-, and gamma-tocopherol), folate and vitamin B12. Using multivariate Cox proportional hazards models, time to clearance analyses of oncogenic HPV infections were conducted for 84 women with at least one oncogenic infection at baseline. Hazard ratios (HR) were estimated for the association of HPV clearance to each nutrient tertile and to determine linear trends.
The likelihood of clearing an oncogenic HPV infection was significantly higher with increasing levels of trans-lycopene (p for trend, 0.025) and cis-lycopene (p for trend, 0.010). The adjusted hazard ratios of the highest tertiles of trans- and cis-lycopene were 2.79 (95% CI = 1.17-6.66) and 2.92 (95% CI = 1.28-6.63) compared with the lowest tertiles.
Higher concentrations of trans- and cis-lycopene may reduce the time to clearance of an oncogenic HPV infection.
数据表明，较高水平的营养素可预防人乳头瘤病毒（HPV）持续感染和宫颈肿瘤形成。本研究评估了循环营养素在致癌性HPV感染清除中的作用。
对女性进行前瞻性随访，在基线时以及基线后约4个月和10个月进行访视。每次访视时，确定15种致癌性HPV类型。在4个月访视时评估血浆中视黄醇、类胡萝卜素（即α-、反式-β-、顺式-β-胡萝卜素、α-、β-隐黄质、叶黄素、玉米黄质、反式和顺式番茄红素）、生育酚（即α-、δ-和γ-生育酚）、叶酸和维生素B12的水平。使用多变量Cox比例风险模型，对84名在基线时至少有一次致癌性感染的女性进行致癌性HPV感染清除时间分析。估计HPV清除与每种营养素三分位数的关联的风险比（HR），并确定线性趋势。
随着反式番茄红素（趋势p值为0.025）和顺式番茄红素（趋势p值为0.010）水平的升高，清除致癌性HPV感染的可能性显著增加。与最低三分位数相比，反式和顺式番茄红素最高三分位数的调整后风险比分别为2.79（95%CI = 1.17 - 6.66）和2.92（95%CI = 1.28 - 6.63）。
较高浓度的反式和顺式番茄红素可能会缩短致癌性HPV感染的清除时间。
