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[吸入性糖皮质激素治疗特发性肺含铁血黄素沉着症:2例报告]

[Inhaled corticosteroids in idiopathic pulmonary hemosiderosis: 2 cases].

作者信息

Ben Halima Nabil, Karray Abderrahmen, Krichen Anas, Feki Hichem, Ben Salah Mounir, Chabchoub Imène, Hachicha Mongia, Mahfoudh Abdelmajid, Triki Ali

机构信息

Service de pédiatrie CHU Hédi Chaker, Sfax.

出版信息

Tunis Med. 2003 Apr;81(4):283-7.

Abstract

Idiopathic pulmonary hemosiderosis, a rare clinical entity, is characterized by bleeding into the alveoli and progressive pulmonary fibrosis. It is usually treated with systemic corticosteriod during acute bleeding episodes and with prolonged courses of oral corticosteroids and/or other immunosuppressant drugs for maintenance therapy. Because prolonged treatment with these agents is frequently associated with significant side effects, favorable response to inhaled corticosteroids would be ideal in this condition. The authors reports 2 cases of idiopathic pulmonary hemosiderosis diagnoses in the pediatric department of Sfax: a 20 month old boy and an 8 year old girl successfully treated with inhaled beclomethazone dipropionate using doses of 500_g/day and low dose oral prednisolone (0.5 mg/kg one day/2).

摘要

特发性肺含铁血黄素沉着症是一种罕见的临床病症,其特征为肺泡出血和进行性肺纤维化。在急性出血发作期间,通常使用全身性皮质类固醇进行治疗,而在维持治疗中则采用长期口服皮质类固醇和/或其他免疫抑制药物。由于长期使用这些药物常常会伴有显著的副作用,因此在这种情况下,对吸入性皮质类固醇产生良好反应将是理想的。作者报告了在斯法克斯儿科诊断出的2例特发性肺含铁血黄素沉着症病例:一名20个月大的男孩和一名8岁女孩,使用丙酸倍氯米松吸入剂量为500微克/天,并联合低剂量口服泼尼松龙(0.5毫克/千克,隔天一次)进行治疗,均取得成功。

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