Levy Barry S, Nassetta William J
P.O. Box 1230, Sherborn,, Massachusetts, 01770USA.
Int J Occup Environ Health. 2003 Apr-Jun;9(2):153-63. doi: 10.1179/oeh.2003.9.2.153.
Manganese, which enters the body primarily via inhalation, can damage the nervous system and respiratory tract, as well as have other adverse effects. Occupational exposures occur mainly in mining, alloy production, processing, ferro-manganese operations, welding, and work with agrochemicals. Among the neurologic effects is an irreversible parkinsonian-like syndrome. An estimated 500,000 to 1.5 million people in the United States have Parkinson's disease, and physicians need to consider manganese exposure in its differential diagnosis. Since 1837, there have been many reports of cases and case series describing manganese toxicity. More recently, there have been epidemiologic studies of its adverse effects on health. Occupational medicine physicians can play critical roles in preventing the adverse health effects of manganese.
锰主要通过吸入进入人体，会损害神经系统和呼吸道，并产生其他不良影响。职业接触主要发生在采矿、合金生产、加工、锰铁作业、焊接以及农用化学品相关工作中。神经系统影响包括一种不可逆的帕金森氏症样综合征。据估计，美国有50万至150万人患有帕金森病，医生在鉴别诊断时需要考虑锰暴露因素。自1837年以来，已有许多关于锰中毒的病例和病例系列报告。最近，也有关于其对健康不良影响的流行病学研究。职业医学医生在预防锰对健康的不良影响方面可发挥关键作用。
