Holmstrup Palle, Poulsen Anne Havemose, Andersen Lone, Skuldbøl Tanja, Fiehn Nils-Erik
Department of Periodontology, School of Dentistry, University of Copenhagen, 20 Nørre Allé DK-2200, Copenhagen, Denmark.
Dent Clin North Am. 2003 Jul;47(3):575-98. doi: 10.1016/s0011-8532(03)00023-5.
An association between periodontal infection and CVD has been revealed in some epidemiologic studies, whereas other studies were unable to demonstrate such an association. A link between the two diseases may be explained by shared established or nonestablished risk factors. Future studies with extended control of confounding factors and intervention studies may add to the understanding of a possible relationship between the diseases. In some cases, IE is caused by dental plaque bacteria. Several studies are suggestive of oral bacteria causing respiratory infection. The pathogenesis and course of a number of other diseases including DM and rheumatoid arthritis have been associated wish periodontitis, but more research is necessary to elucidate possible pathogenic interactions.
一些流行病学研究揭示了牙周感染与心血管疾病之间的关联，而其他研究则未能证实这种关联。这两种疾病之间的联系可能可以通过共同的已确定或未确定的风险因素来解释。未来对混杂因素进行更全面控制的研究和干预性研究可能会增进对这两种疾病之间可能关系的理解。在某些情况下，感染性心内膜炎是由牙菌斑细菌引起的。多项研究表明口腔细菌会导致呼吸道感染。包括糖尿病和类风湿性关节炎在内的许多其他疾病的发病机制和病程都与牙周炎有关，但需要更多研究来阐明可能的致病相互作用。
