Soory M
Periodontology, King's College London Dental Institute at G KT Hospitals, King's College Dental Hospital, Denmark Hill, London SE 5 9RW, UK.
Open Dent J. 2008;2:5-12. doi: 10.2174/1874210600802010005. Epub 2008 Jan 22.
This review addresses the role of adjunctive tetracycline therapy in the management of periodontal diseases and its efficacy in reducing inflammatory burden, oxidative stress and its sequelae in patients with coexisting features of metabolic syndrome. Removal of the dimethylamine group at C4 of the tetracycline molecule reduces its antibiotic properties, enhancing its non-antimicrobial actions; this strategy has aided the development of several chemically modified tetracyclines such as minocycline and doxycycline, by altering different regions of the molecule for focused action on biological targets. Tetracyclines are effective in reducing inflammation by inhibiting matrix metalloproteinases, preventing excessive angiogenesis, inhibiting apoptosis and stimulating bone formation. There are important applications for tetracyclines in the management of diabetic, dyslipidaemic periodontal patients who smoke. The diverse mechanisms of action of tetracyclines in overcoming oxidative stress and enhancing matrix synthesis are discussed in this review.
本综述探讨了辅助性四环素疗法在牙周疾病管理中的作用及其在减轻代谢综合征共存特征患者的炎症负担、氧化应激及其后遗症方面的疗效。去除四环素分子C4位的二甲胺基团会降低其抗菌特性，增强其非抗菌作用；通过改变分子的不同区域以聚焦作用于生物靶点，这一策略有助于开发几种化学修饰的四环素，如米诺环素和多西环素。四环素通过抑制基质金属蛋白酶、防止过度血管生成、抑制细胞凋亡和刺激骨形成来有效减轻炎症。四环素在患有糖尿病、血脂异常且吸烟的牙周病患者的管理中有重要应用。本综述讨论了四环素在克服氧化应激和增强基质合成方面的多种作用机制。
