Jackson Stephen H D, Weale Martin R, Weale Robert A
Department of Health Care of the Elderly, Guy's, King's and St Thomas' School of Medicine, King's College London, East Dulwich Grove, London SE22 8PT, UK.
Arch Gerontol Geriatr. 2003 Mar-Apr;36(2):103-15. doi: 10.1016/s0167-4943(02)00060-2.
Biological age is a concept used loosely and with little objectivity to describe a shortfall between a population cohort average life expectancy and the perceived life expectancy of an individual of the same age. Many biomarkers decline roughly linearly with age with a slope of <1% per annum. The use of a battery of 16 biomarkers is described as a method of calculating an individual biological age. They include: the concentration of prostacyclin in fibroblasts, cell membrane viscosity, the electroretinogram, baroreflex regulation of the heart rate, the concentration of lymphocytes, leucocyte density and velocity, grip strength, cells of the corneal endothelium and the buccal epithelium, neck muscle mobility, and vital capacity. Although not subjected to a prospective validation, the method might provide an objective approach to this widely used concept.
生物学年龄是一个使用较为宽泛且缺乏客观性的概念，用于描述一个人群队列平均预期寿命与同年龄个体的感知预期寿命之间的差距。许多生物标志物随年龄增长大致呈线性下降，每年下降斜率<1%。使用一组16种生物标志物被描述为一种计算个体生物学年龄的方法。它们包括：成纤维细胞中前列环素的浓度、细胞膜粘度、视网膜电图、心率的压力反射调节、淋巴细胞浓度、白细胞密度和速度、握力、角膜内皮细胞和颊上皮细胞、颈部肌肉活动度以及肺活量。尽管该方法未经过前瞻性验证，但可能为这个广泛使用的概念提供一种客观的方法。
