Overeem Sebastiaan, van Vliet Jorine A, Lammers Gert J, Zitman Frans G, Swaab Dick F, Ferrari Michel D
Narcolepsy Research Group, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Lancet Neurol. 2002 Nov;1(7):437-44. doi: 10.1016/s1474-4422(02)00191-6.
Episodic brain disorders (EBD) form an intriguing group of neurological diseases in which at least some of the symptoms occur in attacks. The hypothalamus integrates many brain functions, including endocrine and autonomic control, and governs various body rhythms. It seems a likely site in which the initiation of attacks of EBD can be modulated. Indeed, the hypothalamus has a crucial role in EBD such as narcolepsy and cluster headache. The same may be true for migraine and depression. Here we summarise the evidence supporting an important role for the hypothalamus in the initiation of disease episodes in various EBD. Study of the various pathophysiological concepts of EBD within the context of the hypothalamus may prove a fruitful example of cross-fertilisation between various research areas.
发作性脑疾病（EBD）构成了一组引人关注的神经系统疾病，其中至少部分症状以发作形式出现。下丘脑整合多种脑功能，包括内分泌和自主神经控制，并调节各种身体节律。它似乎是一个可能调节EBD发作起始的部位。事实上，下丘脑在发作性睡病和丛集性头痛等EBD中起着关键作用。偏头痛和抑郁症可能也是如此。在此，我们总结支持下丘脑在各种EBD疾病发作起始中起重要作用的证据。在丘脑背景下研究EBD的各种病理生理概念，可能会成为不同研究领域间交叉融合的一个富有成果的范例。
