Heufelder J, Stiefel S, Pfaender M, Lüdemann L, Grebe G, Heese J
Hahn-Meitner Institut, Augentumortherapie, Glienicker Strasse 100, D-14109 Berlin, Germany.
Med Phys. 2003 Jun;30(6):1235-40. doi: 10.1118/1.1575557.
BANG polymer gel dosimetry using magnetic resonance imaging (MRI) was applied to an ophthalmologic 68 MeV proton beam. The object was to examine the use of BANG gel for the verification of proton fields in eye tumor therapy and to explore the applicability of polymer gel dosimetry in proton therapy under practical aspects. The gel phantoms were irradiated with monoenergetic and modulated proton beams. MRI analysis was carried out at clinical 1.5 and 3 T MR scanners. At constant LET, results show a linear relationship between spin-spin relaxation rates and dose. However, depth dose curves in BANG gel reveal a quenching of the Bragg maximum due to LET effects. The dose response of the gel for monoenergetic protons and spread-out depth dose distributions can be calculated based on ionization chamber measurements. Experiment and calculations show good agreement and indicate that BANG polymer gels might become a valuable tool in proton therapy quality assurance.
利用磁共振成像(MRI)的BANG聚合物凝胶剂量测定法被应用于眼科68 MeV质子束。目的是研究BANG凝胶在眼部肿瘤治疗中质子束验证方面的应用,并从实际角度探索聚合物凝胶剂量测定法在质子治疗中的适用性。用单能和调制质子束对凝胶体模进行照射。在临床1.5 T和3 T MR扫描仪上进行MRI分析。在恒定传能线密度(LET)下,结果显示自旋-自旋弛豫率与剂量之间存在线性关系。然而,BANG凝胶中的深度剂量曲线显示由于LET效应布拉格峰被淬灭。基于电离室测量结果可以计算出凝胶对单能质子的剂量响应以及展宽后的深度剂量分布。实验和计算结果显示出良好的一致性,表明BANG聚合物凝胶可能成为质子治疗质量保证中的一种有价值的工具。