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高分子凝胶剂量测定法。

Polymer gel dosimetry.

机构信息

Institute of Medical Physics, School of Physics, University of Sydney, Australia.

出版信息

Phys Med Biol. 2010 Mar 7;55(5):R1-63. doi: 10.1088/0031-9155/55/5/R01. Epub 2010 Feb 11.

Abstract

Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented.

摘要

高分子凝胶剂量计是由辐射敏感化学物质制成的,这些物质在辐照后会聚合,聚合程度与吸收的辐射剂量有关。与一维剂量计(如电离室)和二维剂量计(如胶片)相比,这些凝胶剂量计具有在三维(3D)空间中独特记录辐射剂量分布的能力,具有特定的优势。在存在陡峭剂量梯度的剂量测量情况下,例如强度调制放射治疗(IMRT)和立体定向放射外科手术,这些优势尤为显著。高分子凝胶剂量计在近距离治疗剂量测量方面也具有特定的优势。潜在的剂量测量应用包括低能 X 射线、高线性能量传递(LET)和质子治疗、放射性核素和硼俘获中子治疗剂量测量。这些 3D 剂量计与软组织具有相同的射线学等效性,其性质可根据应用进行修改。高分子凝胶剂量计中的 3D 辐射剂量分布可以使用磁共振成像(MRI)、光学计算机断层扫描(光学-CT)、X 射线 CT 或超声进行成像。本文回顾了高分子凝胶剂量计的基础科学以及各种评估技术,并介绍了高分子凝胶剂量计的临床剂量测量应用。

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