Congy F, Pelletier S, Langlois P, Khayat D, Homsi T, Emerit J
Service de Médecine Interne, Hôpital Pitié-Salpêtrière, Paris.
Rev Med Interne. 1992 Nov;13(6):451-3.
The authors report the case of a 48 years old man presenting a pancreatic islet cell carcinoma (gastrinoma) with liver, nodes and peritoneal metastases, associated with an elevated alpha-fetoprotein (AFP) concentration. Incomplete remission was first obtained with a chemotherapy using Streptozotocin combined with 5-Fluorouracil, in association with a Somatostatin analogue (SMS 201-995). But when relapses occur, another chemotherapy was not so effective. Serum gastrin and AFP levels had the same evolution and appear to have the same interest to follow the course of the disease.
作者报告了一例48岁男性病例，该患者患有胰岛细胞癌（胃泌素瘤），伴有肝、淋巴结和腹膜转移，且甲胎蛋白（AFP）浓度升高。最初通过使用链脲佐菌素联合5-氟尿嘧啶的化疗，并联合生长抑素类似物（SMS 201-995）获得了不完全缓解。但复发时，另一种化疗效果不佳。血清胃泌素和AFP水平有相同的变化趋势，并且在追踪疾病进程方面似乎具有相同的意义。
