Tanaka M, Murai M, Tokunaga H, Kimura T, Okada S
Eisei Shikenjo Hokoku. 1990(108):159-61.
Chlormadinone acetate was tested for the preparation of the "Chlormadinone Acetate Reference Standard (Control 881)". Analytical data obtained were as follows: loss on drying, 0.00%; infrared spectrum, 1740, 1715, 1658, 1604, 1587, 1256, 1244 cm-1; ultraviolet spectrum, lambda max = 284 nm; absorbance, E1cm1% (284 nm) = 539-549; optical rotation, [alpha]D20: -12.1 degrees; melting point, 214.6 degrees C; thin-layer chromatography, contaminants were not detected until 300 micrograms; high-performance liquid chromatography, one contaminant was detected. On the basis of the above results, this material was authorized as the National Institute of Hygienic Sciences Reference Standard (Control 881).
对醋酸氯地孕酮进行了检测，以制备“醋酸氯地孕酮参考标准品（对照881）”。获得的分析数据如下：干燥失重，0.00%；红外光谱，1740、1715、1658、1604、1587、1256、1244 cm-1；紫外光谱，λmax = 284 nm；吸光度，E1cm1%（284 nm）= 539 - 549；旋光度，[α]D20：-12.1度；熔点，214.6℃；薄层色谱法，直至300微克未检测到污染物；高效液相色谱法，检测到一种污染物。基于上述结果，该物质被批准为国立卫生科学研究所参考标准品（对照881）。
