Rowe Anthony, Kalaitzopoulos Dimitrios, Osmond Michelle, Ghanem Moustafa, Guo Yike
Department of Computing Imperial College, 180 Queens Gate, London, SW7 2RH, UK.
Bioinformatics. 2003;19 Suppl 1:i225-31. doi: 10.1093/bioinformatics/btg1031.
Bioinformatics requires Grid technologies and protocols to build high performance applications without focusing on the low level detail of how the individual Grid components operate.
The Discovery Net system is a middleware that allows service developers to integrate tools based on existing and emerging Grid standards such as web services. Once integrated, these tools can be used to compose reusable workflows using these services that can later be deployed as new services for others to use. Using the Discovery Net system and a range of different bioinformatics tools, we built a Grid based application for Genome Annotation. This includes workflows for automatic nucleotide annotation, annotation of predicted proteins and text analysis based on metabolic profiles and text analysis.
生物信息学需要网格技术和协议来构建高性能应用程序，而无需关注各个网格组件如何运行的底层细节。
发现网系统是一种中间件，它允许服务开发人员基于诸如网络服务等现有和新兴的网格标准来集成工具。一旦集成，这些工具可用于使用这些服务来组合可重复使用的工作流程，这些工作流程随后可作为新服务进行部署以供他人使用。利用发现网系统和一系列不同的生物信息学工具，我们构建了一个基于网格的基因组注释应用程序。这包括自动核苷酸注释、预测蛋白质注释以及基于代谢谱和文本分析的文本分析工作流程。
