Butterweck V, Wall A, Liefländer-Wulf U, Winterhoff H, Nahrstedt A
Department of Pharmacology and Toxicology of the Westphalian Wilhelms University of Münster, Germany.
Pharmacopsychiatry. 1997 Sep;30 Suppl 2:117-24. doi: 10.1055/s-2007-979531.
A commercially available extract of the aerial parts of Hypericum perforatum, LI 160, showed pronounced activity in selected animal bioassays. These include the forced swimming test (FST) and the tail suspension test, used to determine antidepressant activity, and tests indicating activity on the central nervous system, such as body temperature and ketamine induced sleeping time. The counteracting effects of drugs known to interfere with the central dopaminergic system strongly suggested that dopamine mediated activity is important for the activity of the extract. Dose-response experiments of the total extract and of fractions rich in flavonoids and napthodianthrones produced inverted U-shaped dose response curves.
一种市售的贯叶连翘地上部分提取物LI 160，在选定的动物生物测定中显示出显著活性。这些测定包括用于确定抗抑郁活性的强迫游泳试验（FST）和悬尾试验，以及表明对中枢神经系统有活性的试验，如体温和氯胺酮诱导的睡眠时间试验。已知干扰中枢多巴胺能系统的药物的拮抗作用强烈表明，多巴胺介导的活性对提取物的活性很重要。总提取物以及富含黄酮类化合物和萘骈二蒽酮的组分的剂量反应实验产生了倒U形剂量反应曲线。
