患有和未患有高血压的非裔美国中风患者在危险因素概况以及基于CT/MRI的梗死发生率方面是否存在差异？来自非裔美国抗血小板中风预防研究（AAASPS）的报告。

Are there differences in risk factor profiles and frequency of CT/MRI-based infarcts among African American stroke patients with and without hypertension? A report from the African American Antiplatelet Stroke Prevention Study (AAASPS).

作者信息

Whittley Chandra Y, Gorelick Philip B, Raman Rema, Harris Jeffrey, Richardson DeJuran

机构信息

Departments of Neurological Science and Preventive Medicine, Rush Medical College, Chicago, Illinois 60612, USA.

出版信息

J Natl Med Assoc. 2003 Jun;95(6):423-32.

PMID:12856908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2594536/

Abstract

UNLABELLED

BACKGROUND; African Americans (AAs) have a high risk of stroke and a high prevalence of cardiovascular risk factors. Little is known about stroke risk profiles among non-hypertensive AAs.

METHODS

African American Antiplatelet Stroke Prevention Study (AAASPS) enrollees with a history of hypertension (htn) were compared to those without htn for history of traditional cardiovascular risk factors and number and distribution of CT/MRI infarcts. Estimated odds ratios are presented describing the association between selected risk factors and htn status. The estimated odds ratios and 95% confidence intervals (CI) were obtained using multivariate logistic regression.

RESULTS

The database for this analysis included 1012 patients with htn and 74 patients without htn. When compared to those with htn, those without htn were more commonly men (59% vs. 46%; p = 0.030), current cigarette smokers (55% vs. 37%; p = 0.001), were younger (median age: 59 years vs. 62 years; p = 0.064), had higher education (11.7 +/- 2.9 vs. 11.1 +/- 3.1; p = 0.024), had a higher number of acute strokes of unknown cause (23% vs. 13%; p=0.060), and less commonly had a history of diabetes (25% vs. 41%; p = 0.007). Those without htn had a lower mean number of old infarcts on MRI (0.94 +/- 1.40 vs. 1.45 +/- 1.60; p = 0.045), and a higher number of mean recent infarcts on CT (1.30 +/- 1.15 vs. 0.93 +/- 1.01; p = 0.031). Multivariate analysis to predict those without htn showed that these patients were more likely to be current cigarette smokers (OR = 2.89; CI = 1.60,5.49) and have higher education (OR = 1.08, CI = 0.996,1.17), and were less likely to have old CT/MRI-based infarcts (OR = 0.46; CI = 0.26,0.76).

CONCLUSIONS

AAs without htn may have a different cardiovascular risk factor profile and CT/MRI profile than AAs with htn. This baseline profile among AAs without htn may predict lower stroke recurrence rates in this ongoing trial.

摘要

未标注

背景；非裔美国人（AA）中风风险高，心血管危险因素患病率也高。对于非高血压非裔美国人的中风风险概况知之甚少。

方法

将有高血压病史（htn）的非裔美国人抗血小板中风预防研究（AAASPS）参与者与无高血压病史的参与者进行比较，分析传统心血管危险因素史以及CT/MRI梗死灶的数量和分布情况。给出估计比值比，描述选定危险因素与高血压状态之间的关联。使用多因素逻辑回归获得估计比值比和95%置信区间（CI）。

结果

该分析数据库包括1012例有高血压的患者和74例无高血压的患者。与有高血压的患者相比，无高血压的患者男性更常见（59%对46%；p = 0.030），当前吸烟者更多（55%对37%；p = 0.001），更年轻（中位年龄：59岁对62岁；p = 0.064），受教育程度更高（11.7±2.9对11.1±3.1；p = 0.024），不明原因急性中风的数量更多（23%对13%；p = 0.060），糖尿病史更少见（25%对41%；p = 0.007）。无高血压的患者MRI上陈旧梗死灶的平均数量更低（0.94±1.40对1.45±1.60；p = 0.045），CT上近期梗死灶的平均数量更高（1.30±1.15对0.93±1.01；p = 0.031）。预测无高血压患者的多因素分析表明，这些患者更可能是当前吸烟者（OR = 2.89；CI = 1.60，5.49）且受教育程度更高（OR = 1.08，CI = 0.996，1.17），基于CT/MRI的陈旧梗死灶的可能性更小（OR = 0.46；CI = 0.26，0.76）。