Jeppesen D, Hasselbalch H, Ersbøll A K, Heilmann C, Valerius N H
Department of Paediatrics, Copenhagen University Hvidovre Hospital, Hvidovre, Denmark.
Acta Paediatr. 2003 Jun;92(6):679-83.
To examine the size of the thymus in uninfected infants born to HIV-positive mothers and to study the effects of feeding by human donor milk on the size of the thymus in these infants.
The absolute and relative thymic size was assessed by sonography as thymic index (Ti), and the Ti/weight-ratio (Ti/w) at birth and at 4 mo of age in 12 healthy uninfected infants born to HlV-infected mothers. All infants were exclusively fed pasteurized donor milk. The results were compared with those obtained from a previous cohort of exclusively breastfed, partially breastfed and exclusively formula-fed infants.
At birth the Ti was reduced in infants born to HIV-infected mothers in comparison with that in control infants but this difference disappeared when their birthweights were taken into consideration (Ti/w-ratio). At 4 mo of age the geometric mean Ti of infants fed donor milk was 23.8 and the mean Ti/w-ratio was 4.2. Compared with those of exclusively breastfed infants, the Ti and Ti/w-ratio of infants fed donor milk were significantly reduced (p < 0.01). The Ti/w-ratio increased in donor-milk-fed infants compared with that in the formula-fed infants (p = 0.02).
At birth the size of the thymus was smaller in uninfected infants of HIV-positive mothers compared with infants of HIV-negative mothers but when birthweight was taken into account this difference disappeared. Feeding by human donor milk seemed to result in an increased size of the thymus at 4 mo of age compared with thymic size in infants that were exclusively formula fed.
研究感染人类免疫缺陷病毒（HIV）的母亲所生未感染婴儿的胸腺大小，并探讨人乳喂养对这些婴儿胸腺大小的影响。
通过超声检查评估12名感染HIV的母亲所生健康未感染婴儿出生时及4月龄时的胸腺绝对大小和相对大小，以胸腺指数（Ti）及Ti/体重比（Ti/w）表示。所有婴儿均采用巴氏消毒的捐赠母乳纯喂养。将结果与先前一组纯母乳喂养、部分母乳喂养和纯配方奶喂养婴儿的结果进行比较。
与对照婴儿相比，感染HIV的母亲所生婴儿出生时Ti降低，但考虑出生体重后这种差异消失（Ti/w比）。4月龄时，接受捐赠母乳的婴儿Ti几何平均值为23.8，Ti/w比平均值为4.2。与纯母乳喂养婴儿相比，接受捐赠母乳的婴儿Ti及Ti/w比显著降低（p<0.01）。与配方奶喂养婴儿相比，接受捐赠母乳的婴儿Ti/w比升高（p = 0.02）。
与HIV阴性母亲所生婴儿相比，HIV阳性母亲所生未感染婴儿出生时胸腺较小，但考虑出生体重后这种差异消失。与纯配方奶喂养婴儿相比，4月龄时人乳喂养似乎使胸腺增大。
