Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, USA.
Pediatr Radiol. 2011 May;41(5):633-42. doi: 10.1007/s00247-010-1895-0. Epub 2010 Nov 23.
A mother's circulating estrogen increases over the third trimester, producing physiological effects on her newborn that wane postnatally. Estrogenization might be prolonged in newborns exposed to exogenous estrogens, such as isoflavones in soy formula.
We evaluated ultrasonography for monitoring growth of multiple estrogen-responsive organs in healthy infants and developed organ-growth trajectories.
We studied 38 boys (61 visits) from birth to age 6 months and 41 girls (96 visits) from birth to age 1 year using a partly cross-sectional, partly longitudinal design. We measured uterus and ovaries in girls, testes and prostate in boys, and kidneys, breasts, thymus, and thyroid in all children. We imaged all organs from the body surface in one session of < 1 h.
Uterine volume decreased from birth (P < 0.0001), whereas ovarian volume increased sharply until age 2 months and then decreased (P < 0.001). Testicular volume increased with age (P < 0.0001), but prostatic volume showed minimal age trend. Breast bud diameter showed no age trend in girls but declined from birth in boys (P = 0.03).
US examination of multiple estrogen-responsive organs in infants in a single session is feasible and yields volume estimates useful for assessing potential endocrine disruptor effects on organ growth.
母亲的循环雌激素在妊娠晚期增加，对其新生儿产生生理影响，这些影响在产后逐渐消失。如果新生儿接触到外源性雌激素，如大豆配方中的异黄酮，雌激素化可能会延长。
我们评估了超声检查在监测健康婴儿多个雌激素反应器官生长中的作用，并制定了器官生长轨迹。
我们采用部分横断面、部分纵向设计，研究了 38 名男婴（61 次就诊）和 41 名女婴（96 次就诊）从出生到 6 个月龄，以及所有儿童从出生到 1 岁。我们在女孩中测量了子宫和卵巢，在男孩中测量了睾丸和前列腺，在所有儿童中测量了肾脏、乳房、胸腺和甲状腺。我们在不到 1 小时的一次检查中从体表对所有器官进行成像。
子宫体积从出生时开始下降（P<0.0001），而卵巢体积在 2 个月前急剧增加，然后下降（P<0.001）。睾丸体积随年龄增长而增加（P<0.0001），但前列腺体积的年龄趋势最小。女孩的乳腺芽直径没有年龄趋势，但男孩的乳腺芽直径从出生开始下降（P=0.03）。
在单次检查中对婴儿的多个雌激素反应器官进行超声检查是可行的，并且可以获得评估潜在内分泌干扰物对器官生长影响的有用体积估计值。
