Allman David, Miller Juli P
Department of Pathology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.
Immunol Res. 2003;27(2-3):131-40. doi: 10.1385/IR:27:2-3:131.
Precursors for B lymphocytes develop from semirestricted lymphoid progenitors in the bone marrow. Here we review current knowledge on the cellular stages underlying early B cell development from multipotent progenitor cells, and discuss the factors implicated in the regulation of this process. In particular, we will focus on the role of cytokine receptor signaling in early lymphocyte ontogeny and lymphoid lineage commitment, with an emphasis on the role of interleukin- 7 (IL-7) in early lymphocyte development within the bone marrow microenvironment. We will also discuss recent evidence that lymphocytes and subsets of dendritic cells develop from a common pathway, speculating that IL-7 may regulate cell fate decisions in multipotent B/dendritic cell precursors by driving these cells to differentiate into B-lineage-committed cells.
B淋巴细胞的前体由骨髓中半限制性淋巴样祖细胞发育而来。在此，我们综述了目前关于从多能祖细胞开始的早期B细胞发育所涉及的细胞阶段的知识，并讨论了参与该过程调控的因素。特别地，我们将聚焦细胞因子受体信号在早期淋巴细胞个体发生和淋巴谱系定向分化中的作用，重点关注白细胞介素-7（IL-7）在骨髓微环境中早期淋巴细胞发育中的作用。我们还将讨论最近的证据，即淋巴细胞和树突状细胞亚群从共同途径发育而来，并推测IL-7可能通过促使这些细胞分化为B谱系定向细胞来调控多能B/树突状细胞前体中的细胞命运决定。
