Yukioka T, Shimazaki S, Matuda H
Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Clin Ther. 1992 Sep-Oct;14(5):696-8.
The patients were three men and two women with moderate to severe inhalation injury. Each patient received immediate fluid therapy and all required intubation for respiratory management. At some time between 24 and 72 hours after the injury, the synthetic angiotensin analogue (1-Sar, 8-Ile) angiotensin II was infused at a rate of 100 ng/kg/min for 10 minutes, 200 ng/kg/min for another 10 minutes, and 300 ng/kg/min for 30 minutes. The mean (+/- SD) PaO2 increased from 80.8 +/- 26.9 mmHg before to 89.8 +/- 27.3 mmHg after the infusion (P < 0.05) and the PaCO2 decreased from 42.4 +/- 8.3 to 39.6 +/- 7.9 mmHg (P < 0.05). A transient pressor response was noted in all patients. The results suggest that this angiotensin II analogue may be of benefit in the treatment of inhalation injury and other types of acute lung injury.
患者为3名男性和2名女性，均有中度至重度吸入性损伤。每名患者均接受了即刻液体治疗，且都需要进行气管插管以进行呼吸管理。在受伤后24至72小时之间的某个时间，以100 ng/kg/分钟的速率输注合成血管紧张素类似物（1- Sar，8- Ile）血管紧张素II，持续10分钟，然后以200 ng/kg/分钟的速率再输注10分钟，最后以300 ng/kg/分钟的速率输注30分钟。平均（±标准差）动脉血氧分压（PaO2）从输注前的80.8±26.9 mmHg升至输注后的89.8±27.3 mmHg（P <0.05），而动脉血二氧化碳分压（PaCO2）从42.4±8.3降至39.6±7.9 mmHg（P <0.05）。所有患者均出现短暂的升压反应。结果表明，这种血管紧张素II类似物可能对治疗吸入性损伤和其他类型的急性肺损伤有益。
