Yukioka T, Yukioka N, Aulick L H, Goodwin C W, Mason A D, Sugimoto T, Pruitt B A
Surgery. 1986 Feb;99(2):235-44.
(1-Sarcosine, 8-isoleucine) angiotensin II was assessed as a therapeutic agent for acute respiratory distress syndrome with oleic acid pulmonary edema in sheep used as an experimental model. Under general anesthesia with controlled mechanical ventilation with 100% oxygen, 32 sheep received oleic acid (0.075 ml/kg) intravenously. After oleic acid infusion, 20 animals were treated with continuous intravenous infusion of the angiotensin II analogue; nine received 300 ng/kg/min, six received 600 ng/kg/min, and five received 2000 ng/kg/min. Cardiopulmonary measurements were repeated every 30 minutes for 270 minutes. According to time-integrated PaO2, six of 15 animals of the groups given 300 and 600 ng/kg/min (43%) did not respond to the treatment. All animals responded in the group given 2000 ng/kg/min. Animals in the latter group had lower Qs/Qt, PaCO2, and airway resistance than had the control animals. Elevation of pulmonary vascular resistance was limited and mean arterial blood pressure was well maintained. These results reveal that (1-Sar, 8-Ile) angiotensin II is effective in the treatment of oleic acid-induced pulmonary edema.
以油酸诱导绵羊肺水肿建立急性呼吸窘迫综合征实验模型，评估（1-肌氨酸，8-异亮氨酸）血管紧张素II作为该疾病治疗药物的效果。在100%氧气控制机械通气的全身麻醉下，32只绵羊静脉注射油酸（0.075 ml/kg）。注射油酸后，20只动物接受血管紧张素II类似物的持续静脉输注；9只接受300 ng/kg/min，6只接受600 ng/kg/min，5只接受2000 ng/kg/min。每30分钟重复进行心肺测量，共持续270分钟。根据时间积分的动脉血氧分压，接受300和600 ng/kg/min的15只动物中有6只（43%）对治疗无反应。接受2000 ng/kg/min的所有动物均有反应。后一组动物的肺分流率、动脉血二氧化碳分压和气道阻力均低于对照动物。肺血管阻力升高受到限制，平均动脉血压维持良好。这些结果表明，（1-肌氨酸，8-异亮氨酸）血管紧张素II对油酸诱导的肺水肿治疗有效。
