Kerslake S, Morton K E, Versi E, Buchanan N M, Khamashta M, Baguley E, Braude P, Hughes G R
Department of Obstetrics and Gynecology, UMDS, St. Thomas' Hospital, London, England.
Am J Reprod Immunol. 1992 Oct-Dec;28(3-4):172-5. doi: 10.1111/j.1600-0897.1992.tb00784.x.
The management of 56 pregnancies in 54 patients is presented, 52 with systemic lupus erythematosus and two patients with primary antiphospholipid syndrome. All underwent serial Doppler blood flow studies of the umbilical and uterine arteries from 14 weeks of gestation. Drug therapy was directed at disease activity and the fetus and mother monitored intensively to identify optimum time for delivery. End diastolic blood flow (EDF) studies were compared with anticardiolipin antibodies (aCL) and the lupus anticoagulant (LAC) to predict outcome of pregnancy in terms of mortality, Caesarian delivery, hypertension, and gestation. The absence of end-diastolic blood flow predicted Caesarian delivery more accurately. The presence of EDF and the absence of aCL was consistent with a normotensive pregnancy. The presence of LAC was the best of the three in predicting fetal demise.
本文介绍了54例患者的56次妊娠情况，其中52例患有系统性红斑狼疮，2例患有原发性抗磷脂综合征。所有患者均在妊娠14周起接受了脐动脉和子宫动脉的系列多普勒血流研究。药物治疗针对疾病活动情况，对胎儿和母亲进行密切监测以确定最佳分娩时间。将舒张末期血流（EDF）研究结果与抗心磷脂抗体（aCL）和狼疮抗凝物（LAC）进行比较，以预测妊娠结局，包括死亡率、剖宫产、高血压和孕周。舒张末期血流缺失对剖宫产的预测更为准确。存在EDF且不存在aCL与血压正常的妊娠情况相符。在预测胎儿死亡方面，LAC是三者中最有效的。
