Hayslett J P
Department of Medicine, Yale School of Medicine, New Haven, CT 06510-8056.
Am J Reprod Immunol. 1992 Oct-Dec;28(3-4):199-204. doi: 10.1111/j.1600-0897.1992.tb00791.x.
This review provides an analysis of reports published since 1980 on the effect of systemic lupus erythematosus (SLE) on pregnancy and pregnancy outcome. The question whether pregnancy increases clinical flares and the severity of flares in patients with SLE during pregnancy has not been resolved because of difficulty in defining exacerbations of SLE and of preeclampsia. An analysis of major detailed reports indicates that maternal complications are reduced in patients who are in clinical remission prior to the onset of pregnancy compared with women with persistent disease activity. Complications are observed in 30%-50% of patients with inactive disease at onset of gestation. After exclusion of spontaneous abortions during the first trimester, fetal survival was 85%-90% in most reported case series. The best outcomes were reported in patients with inactive disease at onset of pregnancy. It seems likely that some maternal complications and fetal wastage in this population are related to anticardiolipin antibodies.
本综述分析了自1980年以来发表的关于系统性红斑狼疮（SLE）对妊娠及妊娠结局影响的报告。由于难以界定SLE病情加重和先兆子痫，妊娠是否会增加SLE患者临床病情发作及发作的严重程度这一问题尚未得到解决。对主要详细报告的分析表明，与疾病持续活动的女性相比，妊娠前处于临床缓解期的患者母体并发症减少。妊娠开始时疾病无活动的患者中，有30%-50%会出现并发症。排除孕早期自然流产后，在大多数报告的病例系列中，胎儿存活率为85%-90%。妊娠开始时疾病无活动的患者报告的结局最佳。该人群中的一些母体并发症和胎儿丢失似乎与抗心磷脂抗体有关。
