BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetrícia i Neonatologia Fetal i+D Fetal Medicine Research Center, Barcelona, Spain.
Placenta Lab, Department of Obstetrics, Jena University Hospital, Jena, Germany.
Front Immunol. 2022 Aug 17;13:941586. doi: 10.3389/fimmu.2022.941586. eCollection 2022.
Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown cause, which mainly affects women of childbearing age, especially between 15 and 55 years of age. During pregnancy, SLE is associated with a high risk of perinatal morbidity and mortality. Among the most frequent complications are spontaneous abortion, fetal death, prematurity, intrauterine Fetal growth restriction (FGR), and preeclampsia (PE). The pathophysiology underlying obstetric mortality and morbidity in SLE is still under investigation, but several studies in recent years have suggested that placental dysfunction may play a crucial role. Understanding this association will contribute to developing therapeutic options and improving patient management thus reducing the occurrence of adverse pregnancy outcomes in this group of women. In this review, we will focus on the relationship between SLE and placental insufficiency leading to adverse pregnancy outcomes.
系统性红斑狼疮（SLE）是一种病因不明的慢性炎症性自身免疫性疾病，主要影响育龄妇女，尤其是 15 至 55 岁之间的妇女。在怀孕期间，SLE 与围产期发病率和死亡率高有关。最常见的并发症包括自然流产、胎儿死亡、早产、宫内胎儿生长受限（FGR）和子痫前期（PE）。SLE 导致产科发病率和死亡率的病理生理学仍在研究中，但近年来的几项研究表明，胎盘功能障碍可能起关键作用。了解这种关联将有助于开发治疗选择并改善患者管理，从而减少这组妇女不良妊娠结局的发生。在这篇综述中，我们将重点关注 SLE 与导致不良妊娠结局的胎盘功能不全之间的关系。
