Sacks Steven H, Zhou Wuding
Guy's Hospital, King's College, London, Nephrology and Transplantation, London, United Kingdom.
Am J Transplant. 2003 Aug;3(8):927-32. doi: 10.1034/j.1600-6143.2003.00175.x.
The role of innate immunity in allograft injury is just beginning to become clear, and complement is probably one of a number of factors that are activated very early in the course of transplantation. Kidney transplantation into complement-inhibited rats reduces subsequent inflammation of the graft, probably as a result of reduction of ischemia reperfusion damage as well as diminution of immune mediated damage. Closer analysis of the role of locally synthesised components in mice has suggested that regional synthesis of complement proteins, in particular by the renal tubule, may play a more important role than circulating components. A marked effect on the antidonor T cell response may be explained by the triggering of complement receptors present on antigen presenting cells or T cells infiltrating the graft, or by a more direct effect of complement on the liaison between proximal tubule cells and T cells. Therapeutic control is likely to require a shift to a more targeted approach, directed at complement components produced in the extravascular tissue compartment.
固有免疫在同种异体移植损伤中的作用刚刚开始变得清晰，补体可能是移植过程中很早就被激活的多种因素之一。将肾脏移植到补体抑制的大鼠体内可减轻随后的移植物炎症，这可能是由于缺血再灌注损伤的减轻以及免疫介导损伤的减少。对小鼠局部合成成分作用的更深入分析表明，补体蛋白的局部合成，特别是肾小管的合成，可能比循环成分发挥更重要的作用。对抗供体T细胞反应的显著影响可能是由于抗原呈递细胞或浸润移植物的T细胞上存在的补体受体被触发，或者是补体对近端小管细胞与T细胞之间联系的更直接作用。治疗控制可能需要转向更有针对性的方法，针对血管外组织区室中产生的补体成分。
