Mehregan D A, Gibson L E, Mehregan A H
Department of Dermatology, Mayo Clinic, Rochester, MN.
J Dermatol Sci. 1992 Nov;4(3):185-92. doi: 10.1016/0923-1811(92)90018-7.
Malignant blue nevus is uncommon compared to its benign counterpart and is regarded as a rare form of malignant melanoma. We report the clinical and histological findings in eight cases. Histologically, all eight specimens showed no epidermal involvement and had contained within or were adjacent to portions of blue nevus or cellular blue nevus. Proliferation of bundles of bipolar spindle shaped cells with marked cellular atypia, mitotic figures, foci of necrosis, and inflammatory cell infiltrate were noted. Two of the cases were studied by DNA flow cytometry and the populations of tumor cells were found to be diploid. Two cases have died secondary to metastasis. Although malignant blue nevi may not behave as aggressively as nodular malignant melanoma, they have definite potential to do so and therefore should be removed by wide surgical excision.
与良性蓝痣相比，恶性蓝痣较为少见，被视为恶性黑色素瘤的一种罕见类型。我们报告8例的临床及组织学表现。组织学上，所有8个标本均未累及表皮，且包含蓝痣或细胞性蓝痣部分或与之相邻。可见双极梭形细胞束增殖，伴有明显细胞异型性、有丝分裂象、坏死灶及炎症细胞浸润。其中2例进行了DNA流式细胞术研究，发现肿瘤细胞群体为二倍体。2例因转移而死亡。尽管恶性蓝痣的侵袭性可能不如结节性恶性黑色素瘤，但它们确实有这样做的潜力，因此应通过广泛手术切除。
