Connelly J, Smith J L
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030.
Cancer. 1991 May 15;67(10):2653-7. doi: 10.1002/1097-0142(19910515)67:10<2653::aid-cncr2820671041>3.0.co;2-u.
To elucidate the histologic features and biologic behavior of malignant blue nevus (MBN), 12 cases were analyzed in which the tumor showed no junctional activity and arose in a blue nevus background. Seven patients were men and five were women; their mean age was 48.8 years. Eight lesions were on the scalp, and no patient had a family history of melanoma. The histologic appearance of most lesions was a nodule or nodules of malignant cells in a blue nevus. Mitoses were present in all lesions with atypical forms in eight; however the mitotic rate exceeded two per ten high-power fields in only one lesion. Four lesions had necrosis, and four had a heavily pigmented malignant component. Four patients had recurrences; ten patients had metastases, and eight died of their disease. Therefore MBN is an aggressive neoplasm.
为阐明恶性蓝痣（MBN）的组织学特征和生物学行为，对12例肿瘤无交界活性且发生于蓝痣背景的病例进行了分析。7例为男性，5例为女性；平均年龄48.8岁。8个病灶位于头皮，且无患者有黑素瘤家族史。大多数病灶的组织学表现为蓝痣内的一个或多个恶性细胞结节。所有病灶均有核分裂象，其中8例有非典型核分裂象；然而，仅1个病灶的核分裂率超过每10个高倍视野2个。4个病灶有坏死，4个有色素沉着明显的恶性成分。4例患者复发；10例患者发生转移，8例患者死于该病。因此，MBN是一种侵袭性肿瘤。
