Mehregan D A, Mehregan A H
Pinkus Dermatopathology Laboratory, Monroe, Mich.
Arch Dermatol. 1993 Mar;129(3):328-31.
Deep penetrating nevus is a variant of melanocytic nevi with histologic features that may be alarming and can be mistaken for malignant melanoma. We are presenting a review of the clinical findings and the histologic features of deep penetrating nevus in a series of 14 cases.
Deep penetrating nevus occurs most commonly over the acral skin of young adults. Clinically, the lesions were diagnosed as pigmented nevus, blue nevus, or malignant melanoma. Histologically, deep penetrating nevus shows a wedge-shaped lesion extending to the deep dermis and the subcutaneous fat tissue. Nests and fascicles of pigmented melanocytes extended deep at the periphery of blood vessels, nerves, and the cutaneous adnexa. Low-grade cellular atypia is present and mitoses are rare.
Deep penetrating nevus is a variant of benign pigmented nevi with deep dermal and subcutaneous involvement. The pattern should be recognized and differentiated from malignant melanoma.
深部穿透性痣是黑素细胞痣的一种变体，其组织学特征可能令人担忧，且可能被误诊为恶性黑色素瘤。我们对14例深部穿透性痣的临床发现和组织学特征进行了综述。
深部穿透性痣最常见于年轻成年人的肢端皮肤。临床上，这些病变被诊断为色素痣、蓝痣或恶性黑色素瘤。组织学上，深部穿透性痣表现为楔形病变，延伸至真皮深层和皮下脂肪组织。色素性黑素细胞巢和束状结构在血管、神经和皮肤附属器周围向深部延伸。存在低度细胞异型性，有丝分裂罕见。
深部穿透性痣是一种累及真皮深层和皮下组织的良性色素痣变体。应识别该形态并与恶性黑色素瘤相鉴别。
