Moll Heidrun
Institute for Molecular Biology of Infectious Diseases, University of Würzburg, Germany.
Cell Microbiol. 2003 Aug;5(8):493-500. doi: 10.1046/j.1462-5822.2003.00291.x.
Host defence against infection requires an integrated response of both the innate and adaptive arms of the immune system. Emerging data indicate that dendritic cells contribute an essential part to the initiation and regulation of adaptive immunity. Dendritic cells guard the sites of pathogen entry to the host and are uniquely suited to detect and capture invading microbes. Upon recognition of microbial structures and appropriate activation, a maturation programme is triggered and dendritic cells migrate to lymphoid organs to stimulate a primary cell-mediated immune response. Moreover, dendritic cells play a critical role in shaping the emerging response, thereby controlling the course of infection. They can discriminate between various types of microorganisms and are capable of producing different cytokines in response to different microbial stimuli. On the other hand, pathogens developed numerous strategies to evade and subvert dendritic cell functions. Elucidating the interactions of dendritic cells with microbial pathogens may lead to novel strategies for combating infectious diseases by dendritic cell-based vaccination and immunotherapy. This review highlights recent advances in our knowledge of the unique role of dendritic cells in counteracting microbial infections.
宿主抵御感染需要免疫系统的固有免疫和适应性免疫分支的综合反应。新出现的数据表明，树突状细胞对适应性免疫的启动和调节起着至关重要的作用。树突状细胞守卫着病原体进入宿主的部位，并且特别适合检测和捕获入侵的微生物。一旦识别出微生物结构并适当激活，就会触发成熟程序，树突状细胞迁移到淋巴器官以刺激原发性细胞介导的免疫反应。此外，树突状细胞在塑造新出现的反应中起关键作用，从而控制感染进程。它们能够区分各种类型的微生物，并能够根据不同的微生物刺激产生不同的细胞因子。另一方面，病原体制定了许多策略来逃避和破坏树突状细胞的功能。阐明树突状细胞与微生物病原体之间的相互作用可能会带来通过基于树突状细胞的疫苗接种和免疫疗法对抗传染病的新策略。本综述重点介绍了我们对树突状细胞在对抗微生物感染中独特作用的认识的最新进展。
