Jefferies Heather, Coster Jane, Khalil Alizan, Bot Joan, McCauley Rosalie D, Hall John C
Department of Surgery, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia.
ANZ J Surg. 2003 Jul;73(7):517-22. doi: 10.1046/j.1445-1433.2003.02682.x.
Glutathione (GSH) is an ubiquitous thiol-containing tripeptide that plays a key role in cell biology. It modulates cell response to redox changes associated with the reactive oxygen species, detoxifies the metabolites of drugs; regulates gene expression and apoptosis, and is involved in the transmembrane transport of organic solutes. Polymorphism has been observed in key enzymes of GSH metabolism and some alleles have been associated with an impaired redox buffer system downsteam diseases, and susceptibility to ischaemia. These varied activities make GSH an attractive target for a more reductionist approach to the prevention and management of many conditions of interest to surgeons.
谷胱甘肽（GSH）是一种普遍存在的含硫醇三肽，在细胞生物学中起关键作用。它调节细胞对与活性氧相关的氧化还原变化的反应，使药物代谢产物解毒；调节基因表达和细胞凋亡，并参与有机溶质的跨膜运输。在谷胱甘肽代谢的关键酶中已观察到多态性，一些等位基因与下游疾病的氧化还原缓冲系统受损以及缺血易感性有关。这些多样的活性使谷胱甘肽成为一种有吸引力的靶点，可采用更简化的方法来预防和管理外科医生感兴趣的许多病症。
