Saku K, Zhang B, Hirata K, Liu R, Sasaki N, Sakai T, Ying H, Arakawa K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Clin Ther. 1992 Nov-Dec;14(6):813-20.
Forty-five patients with mild to moderate essential hypertension were randomly assigned to receive 10 to 40 mg of manidipine HCl or 15 to 60 mg of delapril daily for 12 months. In the manidipine-treated group were 13 women and 5 men (mean age, 48.2 years) and in the delapril-treated group 11 women and 11 men (mean age, 53.7 years). Blood samples were taken at baseline and after 6 and 12 months of treatment and again at 2 months after treatment discontinuation. Significant reductions in blood pressure were observed in both treatment groups. The reduction in diastolic blood pressure was significantly greater in the manidipine-treated patients than in the delapril-treated patients; no significant between-groups differences in systolic blood pressure were noted. Heart rate increased significantly in the manidipine group. No changes in serum levels of total cholesterol, triglycerides, and high-density and low-density lipoprotein cholesterol were noted during or after treatment. In the manidipine group, a small but significant decrease in apolipoprotein (apo) A-I and an increase in lipoprotein(a) were found at 6 months and a significant increase in apo A-II and apo E at 12 months; in the delapril group a significant decrease in apo A-I was found at 6 months. The results indicate that both manidipine and delapril are lipid-neutral antihypertensive drugs, since neither drug greatly affected serum lipid metabolism.
45例轻度至中度原发性高血压患者被随机分配，分别每日服用10至40毫克盐酸马尼地平或15至60毫克地拉普利，疗程为12个月。服用马尼地平组有13名女性和5名男性（平均年龄48.2岁），服用地拉普利组有11名女性和11名男性（平均年龄53.7岁）。在基线、治疗6个月和12个月后以及停药2个月后采集血样。两个治疗组的血压均显著降低。服用马尼地平的患者舒张压降低幅度显著大于服用地拉普利的患者；收缩压在两组之间未观察到显著差异。马尼地平组心率显著增加。治疗期间及治疗后，总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的血清水平均未发生变化。在马尼地平组，6个月时载脂蛋白（apo）A-I有小幅但显著降低，脂蛋白(a)增加，12个月时apo A-II和apo E显著增加；地拉普利组在6个月时apo A-I显著降低。结果表明，马尼地平和地拉普利都是对血脂无影响的降压药，因为两种药物均未对血清脂质代谢产生重大影响。
