尖锐湿疣患者外周血Th1/Th2细胞平衡的变化。
Changes in peripheral blood Th1/Th2 cell balance in patients with condyloma acuminatum.
作者信息
Li Li, Zhou Zai-gao, Zeng Kang, Liang Liu-ping, Zhou Xian-yi, Yi Zheng-shan
机构信息
Department of Dermatology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2003 Jul;23(7):737-9.
OBJECTIVE
To explore the association of peripheral blood T helper type 1 (Th1) and type 2 (Th2) imbalance with the occurrence of condyloma acuminatum (CA).
METHODS
Interferon-gamma(IFN-gamma) and interleukin-4 (IL-4) secreted by CD4(+) T-cells were detected by flow cytometry in 40 patients with CA and 20 healthy volunteers, and significance of Th1/Th2 cell ratio in the etiology of the CA was analyzed.
RESULTS
Peripheral blood Th1 cells that secreted IFN-gamma were significantly decreased in number in patients with CA (P <0.05), while Th2 cells producing IL-4 increased (P <0.05). The Th1/Th2 cell ratio was significantly reduced in CA patients as compared with the health control subjects (P <0.01).
CONCLUSION
Increases of Th2 cells and decrease of Th1 cells in the peripheral blood of CA patients result in relative Th2 predominance and breach the Th1/Th2 balance, which may play an important role in the etiology and recurrence of CA.
目的
探讨外周血1型辅助性T细胞（Th1）与2型辅助性T细胞（Th2）失衡与尖锐湿疣（CA）发生的相关性。
方法
采用流式细胞术检测40例CA患者和20名健康志愿者CD4(+) T细胞分泌的干扰素-γ（IFN-γ）和白细胞介素-4（IL-4），分析Th1/Th2细胞比值在CA发病机制中的意义。
结果
CA患者外周血中分泌IFN-γ的Th1细胞数量显著减少（P <0.05），而产生IL-4的Th2细胞数量增加（P <0.05）。与健康对照者相比，CA患者的Th1/Th2细胞比值显著降低（P <0.01）。
结论
CA患者外周血中Th2细胞增多、Th1细胞减少，导致Th2相对占优势，打破了Th1/Th2平衡，这可能在CA的发病机制和复发中起重要作用。
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