水杨酸：老药新用与葡萄球菌疾病
Salicylic acid: an old dog, new tricks, and staphylococcal disease.
作者信息
Herrmann Mathias
机构信息
Department of Bacteriology and Hygiene, Institute of Microbiology and Hygiene, Building 43, Kirrberger Street, 66421 Homburg/Saar, Germany.
出版信息
J Clin Invest. 2003 Jul;112(2):149-51. doi: 10.1172/JCI19143.
Abstract
Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and alpha-hemolysin - virulence factors necessary for bacterial replication in host tissues and, now, potential therapeutic targets.
摘要
阿司匹林已被证明可降低金黄色葡萄球菌相关性心内膜炎的毒力。一项新研究表明，阿司匹林的主要代谢产物水杨酸在转录水平发挥作用，下调纤维蛋白原、纤连蛋白和α-溶血素的产生，这些是细菌在宿主组织中复制所必需的毒力因子，也是目前潜在的治疗靶点。
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本文引用的文献
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3
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