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Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus.

作者信息

Zeden Merve Suzan, Burke Órla, Vallely Moya, Fingleton Claire, O'Gara James P

机构信息

Microbiology, School of Natural Sciences, National University of Ireland, Galway, Ireland.

出版信息

PLoS Pathog. 2021 Jan 14;17(1):e1009093. doi: 10.1371/journal.ppat.1009093. eCollection 2021 Jan.

DOI:10.1371/journal.ppat.1009093
PMID:33444418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7808641/
Abstract
摘要

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Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12394-12401. doi: 10.1073/pnas.1922211117. Epub 2020 May 15.
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The Uptake and Release of Amino Acids by at Mid-Exponential and Stationary Phases and Their Corresponding Responses to Changes in Temperature, pH and Osmolality.处于指数中期和稳定期的[具体对象]对氨基酸的摄取与释放及其对温度、pH值和渗透压变化的相应反应
Front Microbiol. 2020 Jan 23;10:3059. doi: 10.3389/fmicb.2019.03059. eCollection 2019.
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Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production.鉴定金黄色葡萄球菌中的主要谷氨酰胺和谷氨酸转运体及其对 c-di-AMP 产生的影响。
Mol Microbiol. 2020 Jun;113(6):1085-1100. doi: 10.1111/mmi.14479. Epub 2020 Feb 11.
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The Staphylococcus aureus Cystine Transporters TcyABC and TcyP Facilitate Nutrient Sulfur Acquisition during Infection.金黄色葡萄球菌胱氨酸转运体 TcyABC 和 TcyP 在感染过程中促进营养物硫的获取。
Infect Immun. 2020 Feb 20;88(3). doi: 10.1128/IAI.00690-19.
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Impaired Alanine Transport or Exposure to d-Cycloserine Increases the Susceptibility of MRSA to β-lactam Antibiotics.丙氨酸转运受损或暴露于 d-环丝氨酸会增加耐甲氧西林金黄色葡萄球菌对β-内酰胺类抗生素的敏感性。
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Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections - United States.生命体征：耐甲氧西林和甲氧西林敏感金黄色葡萄球菌血流感染的流行病学和近期趋势 - 美国。
MMWR Morb Mortal Wkly Rep. 2019 Mar 8;68(9):214-219. doi: 10.15585/mmwr.mm6809e1.
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Branching Out: Alterations in Bacterial Physiology and Virulence Due to Branched-Chain Amino Acid Deprivation.分枝延伸：分枝链氨基酸缺乏导致的细菌生理和毒力改变。
mBio. 2018 Sep 4;9(5):e01188-18. doi: 10.1128/mBio.01188-18.
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Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.金黄色葡萄球菌中支链氨基酸合成的抑制作用是由异亮氨酸通过 CodY 介导的，也可通过富含亮氨酸的衰减子肽介导。
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