Kapasi Zoher F, Ouslander Joseph G, Schnelle John F, Kutner Michael, Fahey John L
Division of Physical Therapy, Department of Rehabilitation Medicine and Center for Health in Aging, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
J Gerontol A Biol Sci Med Sci. 2003 Jul;58(7):636-43. doi: 10.1093/gerona/58.7.m636.
Aging is associated with decline in both cell-mediated and humoral immunity and may contribute to increased incidence and severity of infections in frail elderly. Exercise, depending on intensity, has significant effects on the immune system. We conducted a randomized, controlled clinical trial of a 32-week functionally oriented exercise program in frail elderly living in nursing homes and determined whether the exercise intervention was associated with a change in immune parameters in this frail elderly nursing home population.
Nursing home residents were randomly assigned to an intervention (n = 94) and control group (n = 96). The intervention consisted of a functionally oriented endurance and resistance exercise training that was provided every 2 hours from 8:00 AM to 4:00 PM for 5 days a week for 8 months. Lymphocyte subpopulations, including activation markers (CD28, CD25, HLA-DR), in vitro proliferation, and soluble products of cytokine activity (neopterin and sTNF-RII) in serum were measured by taking blood samples at baseline and after 8 weeks and 32 weeks of the intervention.
Exercise training did not induce changes in lymphocyte subpopulations, activation markers (CD28, CD25, HLA-DR), in vitro proliferation, and soluble products of cytokine activity (neopterin and sTNF-RII) in serum.
A 32-week exercise intervention did not bring about beneficial or detrimental effects on immune parameters in the frail elderly nursing home population and may explain why the intervention was not associated with a change in the incidence of infections in the intervention group compared with the control group.
衰老与细胞介导免疫和体液免疫的衰退相关，可能导致体弱老年人感染的发生率和严重程度增加。运动，取决于其强度，对免疫系统有显著影响。我们对居住在养老院的体弱老年人进行了一项为期32周的功能导向运动计划的随机对照临床试验，以确定运动干预是否与该体弱老年养老院人群的免疫参数变化相关。
养老院居民被随机分配到干预组（n = 94）和对照组（n = 96）。干预包括功能导向的耐力和阻力运动训练，每周5天，每天上午8:00至下午4:00，每2小时进行一次，为期8个月。通过在基线时以及干预8周和32周后采集血样，测量淋巴细胞亚群，包括激活标志物（CD28、CD25、HLA-DR）、体外增殖以及血清中细胞因子活性的可溶性产物（新蝶呤和sTNF-RII）。
运动训练未引起淋巴细胞亚群、激活标志物（CD28、CD25、HLA-DR）、体外增殖以及血清中细胞因子活性的可溶性产物（新蝶呤和sTNF-RII）的变化。
为期32周的运动干预对体弱老年养老院人群的免疫参数没有产生有益或有害影响，这可能解释了为什么与对照组相比，干预组的感染发生率没有变化。
