Rincón H G, Solomon G F, Benton D, Rubenstein L Z
Department of Psychiatry and Behavioral Sciences, Valle del Lili Foundation, Cali, Colombia.
Aging (Milano). 1996 Apr;8(2):109-12. doi: 10.1007/BF03339564.
Six frail male outpatients 70 years and older deemed at risk for fall, but not suffering from serious medical problems nor receiving immune-altering drugs, received an exercise intervention of increasing strenuousness for 60 minutes 3 times a week for 3 months in comparison with 7 controls having no intervention. Psychosocial and immunologic assessments were made at baseline (Time 1), and after 6 (Time 2) and 12 (Time 3) weeks of physical conditioning. Cytotoxic activity of natural killer (NK) cells significantly decreased during the course of the study, in spite of transient exercise-induced increases at times 2 and 3. Despite the many known benefits of exercise, this report suggests its possible adverse effects on NK cell cytotoxicity in the very frail elderly. Mild overexertion in frail old people may be clinically significant in view of the now recognized role of NK cells in the prevention of metastasis.
六名70岁及以上的体弱男性门诊患者被认为有跌倒风险，但未患有严重的医疗问题，也未接受免疫调节药物治疗，他们接受了一项运动干预，每周3次，每次60分钟，运动强度逐渐增加，持续3个月，与之相比，7名对照者未接受干预。在基线期（时间1）以及体能训练6周（时间2）和12周（时间3）后进行了心理社会和免疫学评估。尽管在时间2和时间3时运动引起了自然杀伤（NK）细胞活性短暂升高，但在研究过程中，NK细胞的细胞毒性显著降低。尽管运动有许多已知的益处，但本报告表明，运动可能对非常体弱的老年人的NK细胞细胞毒性产生不利影响。鉴于目前已认识到NK细胞在预防转移中的作用，体弱老年人的轻度运动过度在临床上可能具有重要意义。
