Kim Jeong Jin, Chae Seoung Wan, Hur Gwong Cheung, Cho Sung Jin, Kim Min Kyu, Choi Jimi, Nam Seon Young, Kim Woo Ho, Yang Han-Kwang, Lee Byung Lan
Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea.
Pathobiology. 2002;70(6):353-60. doi: 10.1159/000071276.
The biologic significance of superoxide dismutase (SOD) in transformed gastric carcinoma cells is unclear. The aim of this study was to examine the role of SOD as a prognostic indicator of gastric carcinomas and its association with other clinicopathological factors.
Expression of MnSOD and Cu/ZnSOD was evaluated immunohistochemically in gastric carcinomas and adenomas using tissue-array methods. The correlation between SOD immunoreactivity and clinical outcome or clinicopathological factors was investigated.
MnSOD expression was associated with a poor patient prognosis and was strong in advanced gastric cancer, in the well-differentiated type and in the presence of lymphoid stroma (p < 0.05). On the other hand, there was no association between Cu/ZnSOD expression and patient survival. Cu/ZnSOD immunoreactivity was strong in advanced gastric cancer and in the presence of lymphoid stroma (p < 0.05) and was weak in signet ring cell type.
MnSOD immunoreactivity is significantly associated with poor outcome in gastric carcinoma patients although both MnSOD and Cu/ZnSOD have a connection with several clinicopathological parameters with some overlap.
超氧化物歧化酶（SOD）在转化的胃癌细胞中的生物学意义尚不清楚。本研究的目的是探讨SOD作为胃癌预后指标的作用及其与其他临床病理因素的关系。
采用组织芯片方法，通过免疫组织化学法评估胃癌和腺瘤中锰超氧化物歧化酶（MnSOD）和铜/锌超氧化物歧化酶（Cu/ZnSOD）的表达。研究SOD免疫反应性与临床结局或临床病理因素之间的相关性。
MnSOD表达与患者预后不良相关，在进展期胃癌、高分化型和存在淋巴样间质的情况下表达较强（p<0.05）。另一方面，Cu/ZnSOD表达与患者生存率无关。Cu/ZnSOD免疫反应性在进展期胃癌和存在淋巴样间质的情况下较强（p<0.05），在印戒细胞型中较弱。
尽管MnSOD和Cu/ZnSOD均与一些临床病理参数相关且存在部分重叠，但MnSOD免疫反应性与胃癌患者的不良预后显著相关。
