Grases Felix, Santiago Cristina, Simonet Bartolomé M, Costa-Bauzá Antonia
Laboratory of Renal Lithiasis Research, Faculty of Sciences, University of Balearic Islands, 07071, Palma de Mallorca, Spain.
Clin Chim Acta. 2003 Aug;334(1-2):131-6. doi: 10.1016/s0009-8981(03)00227-4.
Sialolithiasis is a common disease of salivary glands. The etiology of these calculi is little known and their exact mechanism of formation is unknown.
The composition and structure of 21 sialoliths were studied and the composition of the saliva of each corresponding patient was determined (pH, calcium, magnesium, phosphorus, citrate and phytate).
Eighteen sialoliths exhibited similar macro and microstructure, being constituted by hydroxyapatite (HAP) and organic matter, normally arranged in a multilayer structure. The three remaining sialoliths were exclusively constituted by organic matter. The salivary Ca of patients with HAP calculi was significantly higher than that found in the saliva of the healthy group. The salivary phytate concentration of patients with HAP calculi was significantly inferior to that found in patients with calculi exclusively formed by organic matter, as well as to that found in saliva of healthy group. Significant differences between the salivary magnesium concentrations of patients with HAP calculi and the control group were also observed. No significant differences between pH and citrate concentrations of the three groups were found.
It was concluded that the deficit of crystallization inhibitors such as myo-inositol hexaphosphate (phytate) was also an important etiologic factor implied in the sialolith development.
涎石病是唾液腺的一种常见疾病。这些结石的病因鲜为人知，其确切形成机制尚不清楚。
研究了21颗涎石的组成和结构，并测定了每位相应患者唾液的组成（pH值、钙、镁、磷、柠檬酸盐和植酸盐）。
18颗涎石表现出相似的宏观和微观结构，由羟基磷灰石（HAP）和有机物组成，通常呈多层结构排列。其余三颗涎石仅由有机物组成。HAP结石患者的唾液钙含量显著高于健康组唾液中的钙含量。HAP结石患者的唾液植酸盐浓度显著低于仅由有机物形成结石的患者以及健康组唾液中的植酸盐浓度。还观察到HAP结石患者与对照组唾液镁浓度之间存在显著差异。三组的pH值和柠檬酸盐浓度之间未发现显著差异。
得出的结论是，诸如肌醇六磷酸（植酸盐）等结晶抑制剂的缺乏也是涎石形成过程中的一个重要病因。
