Hülse M, Partsch C J
Laryngol Rhinol Otol (Stuttg). 1975 Dec;54(12):977-85.
Exactly 30 years ago D. C. Cogan reported 4 cases of "nonsyphilitic interstitial keratitis associated with vestibulo-auditory symptoms". Report of 57 of these cases have come to our attention. They mostly concern relatively young people, although the age range is now 4-1/2 to 63 years. The etiology of Cogan's syndrome is unknown. It very frequently has been associated with some generalized vascular diseases. In our first case, a 13 year old boy, we found the symptoms of a serous meningitis with pathological signs in the EEG. No vascular changes were encountered. During 4 weeks the rapidly progressive hearing loss was accompanied by tinnitus and vertigo and an interstitial keratitis. The recession of vestibular symptoms is followed by the loss of function of the endorgans. The voice seemed high-pitched and monotonous. In our patient the eye condition improved, but the cochleo-vestibular disturbances did not. The second case, a 27 year old woman, could be observed over a period of 19 years. The ocular symptoms disappeared nearly completely after 1 year, but the cochleo-vestibular disturbances remained. The audition shows even after 19 years some fluctuations.
整整30年前，D. C. 科根报告了4例“与前庭听觉症状相关的非梅毒性间质性角膜炎”。我们已注意到57例此类病例的报告。这些病例大多涉及相对年轻的人群，不过年龄范围目前为4岁半至63岁。科根综合征的病因不明。它常常与一些全身性血管疾病相关。在我们的第一例病例中，一名13岁男孩，我们在脑电图中发现了伴有病理体征的浆液性脑膜炎症状。未发现血管变化。在4周内，快速进展的听力损失伴有耳鸣、眩晕和间质性角膜炎。前庭症状消退后，内耳器官功能丧失。声音似乎高亢且单调。在我们的患者中，眼部状况有所改善，但耳蜗前庭障碍没有改善。第二例病例，一名27岁女性，观察了19年。眼部症状在1年后几乎完全消失，但耳蜗前庭障碍依然存在。即使在19年后，听力仍有一些波动。
