Amelink Arjen, Bard Martin P L, Burgers Sjaak A, Sterenborg Henricus J C M
Erasmus MC, P.O. Box 5201, 3008 AE Rotterdam, The Netherlands.
Appl Opt. 2003 Jul 1;42(19):4095-101. doi: 10.1364/ao.42.004095.
We report on the development of an optical-fiber-based diagnostic tool that is sensitive to single-scattering events close to the fiber-optic probe tip. By using a single fiber to deliver and detect white light we optimised the detection probability of singly scattered photons from small depths. The sampling depth of this delivery-and-collection fiber was investigated by use of a tissue phantom. We found that for our phantom 90% of the single-scattering signal in the delivery-and-collection fiber originated from less than 200 microm from the fiber tip. The contribution of multiply scattered light from a greater depth to the signal was measured with an additional collection fiber. Several tissue phantoms demonstrated our fiber-optic probes sensitivity to light scattering from superficial layers of tissue and thereby its potential to detect superficial precancerous epithelial lesions.
我们报告了一种基于光纤的诊断工具的开发情况，该工具对靠近光纤探头尖端的单次散射事件敏感。通过使用单根光纤来传输和检测白光，我们优化了从小深度处单次散射光子的检测概率。利用组织模型研究了这种传输与收集光纤的采样深度。我们发现，对于我们的模型，传输与收集光纤中90%的单次散射信号源自距离光纤尖端小于200微米的区域。使用额外的收集光纤测量了来自更大深度的多次散射光对信号的贡献。几种组织模型证明了我们的光纤探头对组织表层光散射的敏感性，从而证明了其检测表层癌前上皮病变的潜力。
