Fanaki N H, el-Nakeeb M A
Department of Pharmaceutical Microbiology, Alexandria University, Egypt.
J Chemother. 1992 Dec;4(6):347-52. doi: 10.1080/1120009x.1992.11739190.
The antimicrobial activity of benzydamine (BD), a non-steroid anti-inflammatory agent, was studied using different techniques against 38 strains belonging to 12 microbial species comprising bacteria, yeasts and a fungus. The minimum inhibitory concentrations, minimum lethal concentrations, per cent survivors after 30-minute exposure to BD (0.1%), growth curves of 7 selected organisms in subinhibitory BD concentrations and killing times for clinical isolates at different BD levels (0.05-0.15%) were determined. The data obtained throughout this study show that BD is a general antimicrobial agent with a rapid biocidal activity against a variety of organisms at concentrations less than those advocated for treatment of inflammatory conditions.
研究了非甾体抗炎药苄达明（BD）对12种微生物（包括细菌、酵母和一种真菌）的38个菌株的抗菌活性，采用了不同技术。测定了最低抑菌浓度、最低致死浓度、暴露于BD（0.1%）30分钟后的存活百分比、7种选定微生物在亚抑菌BD浓度下的生长曲线以及不同BD水平（0.05 - 0.15%）下临床分离株的杀灭时间。整个研究获得的数据表明，BD是一种通用抗菌剂，在低于治疗炎症所推荐的浓度下，对多种生物体具有快速杀菌活性。
