Dick Danielle M, Foroud Tatiana
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alcohol Res Health. 2002;26(3):172-80.
Researchers are using a variety of sophisticated approaches to identify genes that contribute to the development of alcoholism in humans or influence other alcohol-related traits. These strategies include linkage approaches, which can identify broad chromosomal regions that are likely to contain genes predisposing to the disorder, and association approaches, which test the association between a particular marker allele and a specific outcome. Animal studies using diverse strategies can also help identify genes or DNA regions that influence alcohol-related traits in humans. The results of these analyses are likely to have implications for fields such as genetic counseling, gene therapy, and pharmacogenetics.
研究人员正在使用各种复杂的方法来识别导致人类酗酒或影响其他与酒精相关特征的基因。这些策略包括连锁分析方法，该方法可以识别可能包含导致该疾病的基因的广泛染色体区域；以及关联分析方法，该方法测试特定标记等位基因与特定结果之间的关联。使用不同策略的动物研究也有助于识别影响人类酒精相关特征的基因或DNA区域。这些分析结果可能会对遗传咨询、基因治疗和药物遗传学等领域产生影响。
