Osganian Stavroula K, Stampfer Meir J, Rimm Eric, Spiegelman Donna, Hu Frank B, Manson JoAnn E, Willett Walter C
Department of Medicine, Children's Hospital, Boston, Massachusetts, USA.
J Am Coll Cardiol. 2003 Jul 16;42(2):246-52. doi: 10.1016/s0735-1097(03)00575-8.
Our objective was to prospectively examine the relation between vitamin C intake and risk of coronary heart disease (CHD) in women.
Results from prospective investigations of the relation between vitamin C intake and risk of CHD have been inconsistent. The lack of clear evidence for a protective association despite a plausible mechanism indicates the need to evaluate further the association between vitamin C intake and risk of CHD.
In 1980, 85,118 female nurses completed a detailed semiquantitative food-frequency questionnaire that assessed their consumption of vitamin C and other nutrients. Nurses were followed up for 16 years for the development of incident CHD (nonfatal myocardial infarction and fatal CHD).
During 16 years of follow-up (1,240,566 person-years), we identified 1,356 incident cases of CHD. After adjustment for age, smoking, and a variety of other coronary risk factors, we observed a modest significant inverse association between total intake of vitamin C and risk of CHD (relative risk [RR] = 0.73; 95% confidence interval [CI] 0.57 to 0.94). Among women who did not use vitamin C supplements or multivitamins, the association between intake of vitamin C from diet alone and incidence of CHD was weak and not significant (RR = 0.86; 95% CI 0.59 to 1.26). In multivariate models adjusting for age, smoking, and a variety of other coronary risk factors, vitamin C supplement use was associated with a significantly lower risk of CHD (RR = 0.72; 95% CI 0.61 to 0.86).
Users of vitamin C supplements appear to be at lower risk for CHD.
我们的目的是前瞻性地研究女性维生素C摄入量与冠心病（CHD）风险之间的关系。
关于维生素C摄入量与冠心病风险之间关系的前瞻性研究结果并不一致。尽管有合理的机制，但缺乏明确的保护关联证据表明需要进一步评估维生素C摄入量与冠心病风险之间的关联。
1980年，85118名女护士完成了一份详细的半定量食物频率问卷，该问卷评估了她们维生素C和其他营养素的摄入量。对护士进行了16年的随访，以观察冠心病（非致命性心肌梗死和致命性冠心病）的发病情况。
在16年的随访期间（1240566人年），我们确定了1356例冠心病发病病例。在调整年龄、吸烟和其他多种冠心病危险因素后，我们观察到维生素C总摄入量与冠心病风险之间存在适度显著的负相关（相对风险[RR]=0.73；95%置信区间[CI]0.57至0.94）。在未使用维生素C补充剂或复合维生素的女性中，仅从饮食中摄入维生素C与冠心病发病率之间的关联较弱且不显著（RR=0.86；95%CI 0.59至1.26）。在调整年龄、吸烟和其他多种冠心病危险因素的多变量模型中，使用维生素C补充剂与显著较低的冠心病风险相关（RR=0.72；95%CI 0.61至0.86）。
使用维生素C补充剂的人患冠心病的风险似乎较低。
