Grant C C, Harnden A R, Jewell G, Knox K, Peto T E, Crook D W
Department of Paediatrics, University of Auckland, New Zealand.
Arch Dis Child. 2003 Aug;88(8):712-4. doi: 10.1136/adc.88.8.712.
To describe a series of children with invasive pneumococcal disease (IPD).
A review of patient records for children aged 0-18 years admitted to the John Radcliffe Hospital with IPD from 1985 to 2001. Social deprivation was measured by the Jarman index. The proportion of children with congenital abnormalities was compared with national data.
We identified 140 children with IPD; complete data were available for 136 children. The median age at diagnosis was 1.5 years. The social deprivation score of households of children with IPD was higher than that of the average Oxfordshire household (-2.5 v -7.3, p < 0.001). Forty four per cent of cases had at least one preceding health problem. The children with preceding health problems were significantly older than those with no preceding problems (median age 2.67 years, interquartile range 1.21 to 6.20 versus 1.11 years, interquartile range 0.51 to 2.21; p < 0.001). There was an increased risk of IPD for children with central nervous system malformations (OR = 99, 95% CI 31 to 236), congenital heart disease (OR = 62, 95% CI 24 to 131), and chromosomal abnormalities (OR = 32, 95% CI 6.6 to 96).
There is an increased risk of IPD associated with increased social deprivation; and also with central nervous system malformations, congenital heart disease, and chromosomal abnormalities.
描述一系列侵袭性肺炎球菌疾病（IPD）患儿的情况。
回顾1985年至2001年入住约翰·拉德克利夫医院的0至18岁IPD患儿的病历。社会剥夺程度用贾曼指数衡量。将先天性异常患儿的比例与全国数据进行比较。
我们确定了140例IPD患儿；136例患儿有完整数据。诊断时的中位年龄为1.5岁。IPD患儿家庭的社会剥夺得分高于牛津郡平均家庭（-2.5对-7.3，p<0.001）。44%的病例至少有一个先前的健康问题。有先前健康问题的患儿明显比没有先前问题的患儿年龄大（中位年龄2.67岁，四分位间距1.21至6.20岁，而无先前问题的患儿中位年龄为1.11岁，四分位间距0.51至2.21岁；p<0.001）。患有中枢神经系统畸形（比值比=99，95%可信区间31至236）、先天性心脏病（比值比=62，95%可信区间24至131）和染色体异常（比值比=32，95%可信区间6.6至96）的患儿患IPD的风险增加。
IPD风险增加与社会剥夺程度增加相关；也与中枢神经系统畸形、先天性心脏病和染色体异常有关。
